Listeriosis Leighton e. Cluff
Listeriosis Leighton anthrax: report of 117 cases. Arch. Intern. Med: (Chicago), 96:387, 1955. Plotkin, s. A., brahman, p. S., Russell, m., Bumford, f. H., and Atchison, m. M.: An epidemic of inhalation anthrax, first in the twentieth century. I. Clinical features. Amer. J. Med., 29:992, 1960. Smith, h., • and keppie, j.: studies on the chemical basis of pathogenicity of Bacillus anthracis using organisms grown in vivo. In Howie, j. W., and O'Hara, a. J: (eds.): mechanisms of microbial pathogenicity. London, Cambridge ‘university press, 1955.
Listeriosis Leighton e. Cluff
definition. Listeriosis is an infectious disease of animals and man with exceptionally protean manifestations, including meningitis, disseminated granulomas, lymphadenopathy, respiratory symptoms, and ill-defined acute febrile illness. Infection of the human being with listeria monocytogenes was identified in 1929 by felt.it ferments a number of sugars, wit_h the formation of acid but no gas. It can be grown on nutrient agar or broth, preferably containing 1 percent glucose, and produces beta hemolysis on blood agar. L. Monocytogenes resembles very-pelothrix rhuziopathiae and diphtheroid but can be differentiated from these bacteria by its motility (best at 20 to 30° c.), its specific antigenicity, and it is animal pathogenicity.
Incidence and prevalence.it has been recognized more frequently in humans in recent years, but its true incidence is not known. In addition, the diverse manifestations of the dis-ease render it difficult to identify clinically. Epidemiology. Listeriosis may develop follow-ing inhalation, ingestion, or direct contact with contaminated food or animal products. The dis-ease is more common in persons living in rural areas. Person to person probably does not occur. Women can carry listeria in the. Vagina and infection may be transmitted venereally. Whether or not a man can be an asymptomatic carrier of listeria under other conditions is not known.
Pathology and pathogenesis. Lesions may develop in the liver, intestinal tract, skin, mucous membranes of the respiratory tract, lung, heart, spleen, lymph nodes, placenta, and brain. The fetus may be infected transplacentally through the umbilical vein, with the production of septicemia. It is characterized at the onset by symptoms of headache, myalgia, fever, chills, nausea, vomiting, and photophobia, followed by the development of stiff neck, stupor, convulsions, somnolence, and, finally, death. The onset may be abrupt or gradual, and the initial symptoms may be those of gastrointestinal or respiratory illness.
Febrile pharyngitis with cervical and generalized lymphadenopathy can be caused by listeria and may be difficult to differentiate from infectious mononucleosis. Blood leukocytes occasional-ly increase in number with a more or less pronounced monocytosis. Lymph node enlargement in the neck and else-where without respiratory symptoms may also be attributed to listeriosis.