Bacterial Followed by Streptomycin


Bacterial Followed by Streptomycin

The so-called broad-spectrum drugs such as Streptomycin and chloramphenicol are also useful against the Enterobacteriaceae. Large doses of penicillin G are effective against many of the gram-positive and some gram-negative anaerobes. Tetracycline and chloramphenicol are useful for Bacteroides, whereas Pseudomonas will generally respond only to drugs such as polymyxin B or colistin methanesulfonate (polymyxin E) and gentamicin. Carbenicillin is a new semisynthetic Penicillin that may be of considerable value in the treatment of Pseudomonas, Enterobacter, and Proteus infections. The problems are the large doses required, development of resistance, the tendency for sodium overload, and high cost.

Streptomycin this treatment would include an avitaminosis drug, a broad-spectrum drug, and penicillin G. Ampicillin and cephalothin (or phallocentric are considered to have generally similar properties to penicillin G, and usually would not be used simultaneously. At times, they offer special advantages over penicillin, because both ampicillin and the phallocentrism are active against many gram-negative bacteria as well as gram-positive cocci. The phallocentrism is generally more active against Kielbasi than is ampicillin, but ampicillin is much more effective against streptococci. The cephalosporins are also useful in patients allergic to penicillin. The inherent toxicity of the polymyxins should restrict their use mainly to the treatment of Pseudo-monas. appear to be good.

This requires monitoring of the central venous pressure by a well-placed catheter in the superior vena cava or right atrium in an attempt to achieve a pressure of about 8 to 12 cm. of water. and flinging that DISEASES $87 cited by obstruction or many previous episodes will generally respond to oral therapy wi I sulfonamides, tetracycline, ampicillin, chloramphenicol, nalidixic acid, or nitrofurantoin. The last-named drug is particularly useful in recurrent-. infections because of relatively less frequency cc emergence of resistant strains. Drugs are selected on the basis of relative cost, side effects, and anti-microbial sensitivity, all of which may be highly variable. of failure with lower doses.

Recurrence within a few weeks after treatment is usually due to the persistence of the same focus, whereas Dater Streptomycin, particularly in females, is more often the result of reinfection. These agents require acid urine, preferably at pH 5.5. This may be achieved by the addition of a high protein diet, ammonium chloride; or methionine. The dose can be titrated downward by measuring urinary pH. Prophylaxis should not be given for more than three to six months if at all possible and should be abandoned. if bacteriuria persists or recurs. Sepsis in these cases is usually due to' obstruction' and should be promptly relieved.


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